Research Paper in Herbal Chemistry

A Review of Polyherbal Formulation “Sagadevi Nei” (Vernonia cinerea ghee) in the Management of Chronic Kidney Disorders

B. Abarna. V. Manjari., R. Madhavan;DOI: 10.24214/IJGHC/HC/13/1/00114.

Chronic Kidney disease is an emerging non-communicable disease with progressive degeneration of renal tubules leading to abnormal excretion of albumin in urine and increased levels of serum creatinine and blood urea. It is more prevalent in patients with diabetes mellitus and hypertension. Sagadevi Nei is a Siddha polyherbal formulation with 11 ingredients, mainly consisting of leaf juice of Vernonia cinerea, it is indicated for the treatment of oliguria and anuria (Neersurukku, Neerkattu) i.e., reduced urinary output and absence of urination. Sagadevi Nei has been proven for its anti-microbial activity [3] against UTI-causing microbes and E. coli biofilm prevention. This review aims to assess the polyherbal formulation “Sagadevi Nei” (SN) for the management of chronic kidney disease (CKD). The constituents of this formulation have also been proven for their antioxidant, anti-inflammatory, diuretic, and nephroprotective activities. Especially the main ingredient, Vernonia cinerea, has been demonstrated for its ability to regenerate the renal tubules [4]. This review concludes that the ingredients of Sagadevi Nei have nephroprotective, diuretic, antioxidant, and anti-inflammatory effects. Further preclinical studies in compound formulation of Sagadevi Nei help to explore its nephroprotective effect.

Agropharniya  Adhayaya in Shushruta Samhita the basics of modern surgery : a review article

Dr. Rajeev Kumar , Dr. Garima Prateek Singh, Dr. Gayatri , Dr Sonia Shekhawat,DOI: 10.24214/IJGHC/HC/13/1/01522

Acharya Sushruta, the Father of Surgery has very scientifically and elaborately described about the principles of surgery, Vran, Yantra Shastra, Bandhan, procedures etc. Sushruta Samhita Sutra sthana is completely dedicated for basic principles of surgery. Fifth chapter Agropharniya Adhaya is dedicated for preoperative, intraoperative and post operative management of patient, beginning from collection of the equipments and material required for procedure, maintainance of the patient throughout the surgery, early and better recovery of the patient. He has clearly defined the qualities for Shalya Chikitsak for better performance in surgery. All the text although very ancient is holding on its relevance in accordance with present era surgery. This review article is an attempt to describe the sutra of the chapter in relevance with principles of modern surgery to re-establish and bring into light the importance of ancient Suhruta Samhita.

Chemical investigation of some biologically important plant constituents

Dr.Radheykant Sharma,DOI: 10.24214/IJGHC/HC/13/1/02337.

Plants had been used for medicinal purposes long before recorded history. Ancient Chinese and Egyptian papyrus writings describe medicinal uses for plants as early as 3000 BC. Indigenous cultures (such as African and Native American) used herbs in their healing rituals, while others developed traditional medical systems (such as Ayurveda and Traditional Chinese Medicine) in which herbal therapies were used. Researchers found that people in different place of the world tended to use the same or similar plants for the same purposes. Ayurvedic medicines are used to cure several diseases as the herbs mentioned in ayurvedic texts are considered safe for human consumption. Indigenous plants have been used for thousands of years of ayurveda for its diverse healing properties. It is mentioned by Charak in the Charak Samhita, an ancient ayurvedic text.

Swabhavika Vyadhi in Ayurveda: A Review article

Dr. Rajeev Kumar, Dr. Gayatri, Dr. Garima Prateek Singh , Dr Tushita Badhani,

In present era due to busy schedule, people are very busy to maintain the proper care and time for their diet and sleep. Because of sedentary life style even they suppress their natural urges like Kshudha (Hunger), Pipasa (Thirst), Nidara (Sleep) etc. leads to nutritional disorders and fatigue, mental disorders, insomnia, etc.  In Ayurveda these are included in Swabhavika vyadhi (incurable disease) which are Kshudha, Pipasa, Jara, Mrityu, Nidara either in natural or unnatural form. Ayurveda provide various methods to overcome this unnatural disease by using Rasayana, Ritucharya, Dincharya etc.

Comparative Clinical Evaluation of Agnikarma and Jalaukavacharana in Snayugata Vata W.S.R. To Tennis Elbow

Dr Sonia Shekhawat, Dr Devesh Shukla, Dr Rajeev Kumar and Dr Jeeshan Khan,DOI: 10.24214/IJGHC/HC/13/1/04460.

Agnikarma (therapeutic heat burns) and Jalaukavacharana (leech therapy) are the treatment options mentioned in Ayurvedic texts to relieve the clinical condition of Tennis Elbow (Snayugata Vata), which occur due to repetitive activities of the hand, wrist and forearm. It is a degenerative disease that presents pain during routine daily activities and tenderness around the lateral epicondyle. To evaluate and compare the efficacy of Agnikarma and Jalaukavacharana in the management of Snayugata Vata (Tennis Elbow). After obtaining CTRI registration, a total of 30 patients with tennis elbow were registered and allocated into two groups by a simple random sampling method. 15 patients were treated with Agnikarma (Group A) by Lohadhatu Shalaka around the lateral epicondyle of the humerus in 3 sittings at a 10-day interval, and 15 patients were treated with Jalaukavacharana (Group B) around the lateral epicondyle of the humerus in 5 sittings at a 7-day interval. Mann-Whitney U test is carried out for comparison between Group A and Group B. From the above test, we can observe that the p-value for half of the parameters is less than 0.05 and that the other half is greater than 0.05. Hence, we can conclude that there is a significant difference between Group A and Group B. Further, we can observe that the mean rank of Group A is greater than that of Group B. Hence, we can conclude that the statistical effect observed in Group A is better than in Group B. The average percentage effect of Agnikarma is 80.22%, and that of Jalaukavacharana is 71.08%. Hence, both therapies are effective for tennis elbow. 66.67% (10 patients) of patients showed moderate improvement, and 33.33% had marked improvement after Agnikarma. In Jalaukavacharana, 60% (09) of patients had moderate improvement, whereas 33.33% (05) had mild improvement and 1 patient got marked improvement.Both procedures are non-pharmacological and non-invasive, and OPD-level procedures require minimum equipment. Thus, it is concluded that both therapies are effective for tennis elbow. Agnikarma has a better effect than Jalaukavacharana statistically

A Clinical Study to Evaluate the Efficacy of Brahmi Tablet Along with Shirodhara in The Management of Dementia In The Elderly

Dr. Bhaskar Pal, Prof. (Dr.) B.P. Sarma, Dr. S. Kalita, Dr. R. Kalita, Dr. M.Dewan ,DOI: 10.24214/IJGHC/HC/13/1/06178

The alarming increasing rate of Dementia due to Alzheimer’s disease in the elderly is really a matter of serious concern, as it has qualitative and quantitative impact on the health and socio conics issues of the modern society. Smritbhramsa, smritinasa related to mind, psyche was well recognised in various ayurvedic classics in treatment and diagnostic protocol, as well it means loss of memory. In the scarcity of much effective modern measures /medicine in medical fraternity, it is a demand of time the silent killer and cause of huge agony and social stigma due to dementia needs an affordable and inclusive ayurvedic remedial gestures for it’s relief and recovery as the senior citizen’s life style and status are affected by this problem sadly related to memory that is smriti due to degeneration of cerebral neurons. My study has taken the opportunity to incorporating the evidence from review of ayurvedic therapeutic drug and procedure using a much effective herb brahmi and shirodhara procedure for combat the threat to the society. The study was sited on O.P.D. and I.P.D. of kayachikitsa (internal medicine) department, Govt. ayurvedic college and hospital, Guwahati Assam-14 under the guidance of Prof (Dr.) B.P. Sarma, co-guidance of S.Kalita (associate professor), Dr. R. Kalita (assistant professor), Dr. M.Dewan (assistant professor). 32 dementia patients were randomly selected on the basis of 5 points global clinical dementia rating (CDR) scale covering 6 cognitive areas are as subjective parameters within the age group of 60 years to 80 years, irrespective of sex, caste, creed, status in a 1 arm for the intervention with brahmi tablet (500mg each) twice daily for 30 days and Shirodhara procedure (for 30 min/patitent / day) for 7 days shows high significance of brahmi and Shirodhara, by using statistical tool t-test which gives a dimention of altitude in the clinical dementia management through ayurvedic treatment protocol. 

An Analytical Study to Evaluate the Superior Form of Loha Dhatu in The Preparation of Lohasava

Mohanan M. and Menakshi Pachori ,DOI: 10.24214/IJGHC/HC/13/1/08088

Since time immemorial the fermentative preparations are known for their therapeutic efficacy and longer shelf life. Classical references about the addition of purified metals in to the fermentative preparations are in vogue. The uncertainty about the form in which these metals are to be added and to what extend one can anticipate the metallic properties in to the preparation are the corner to be focussed. Here Lohasava is taken up for the pharmaceutical and analytical study, where in Loha dhatu is added in its different purified forms (i.e., Lohabhasma, Lohachurna, Lohadrava) to the Lohasava. Based on initiation and quick completion of fermentation, better organoleptic characters, and the availability of metal it can be concluded that Loha Churna is economical, providing higher concentration of the iron. To rule out the above said dilemmas about the form of metal to be added and it extend of absorption in to the preparation, this works appears significant.